| abstract |
The present invention provides highly active cyclic dinucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor, known as STING (stimulator of interferon genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent type I interferon production, where the cyclic purine dinucleotides that are present in The composition is basically pure CDN 2 ', 5', 2 ', 5' and 2 ', 5', 3 ', 5' and preferably Rp, Rp stereoisomers thereof. |