| abstract |
New processes are provided herein for the preparation of aminosulfone intermediates for the synthesis of 2 - [1 - (3-ethoxy-4-methoxyphenyl) -2-methylsulfonylethyl] -4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-alpha. Processes are also provided for the commercial production of (S) -1 - (3-ethoxy-4-methoxyphenyl) -2-methanesulfonylethylamino. |