| abstract |
The present invention relates, in general terms, to novel compounds in relation to the diagnosis and treatment of pathologies related to the Hedgehog trajectory, including, but not limited to, tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. . The present invention includes novel compounds, novel compositions, methods for their use, and methods for their manufacture, wherein these compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involves methods for inhibiting tumorigenesis, tumor growth, and tumor survival, using agents that inhibit the Hedgehog and Smo signaling pathway. |