| abstract |
The invention provides non-naturally occurring microbial organisms having a 4- hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4- hydroxybutyryl-CoA and/or putrescine pathway and being capable of producing 4- hydroxybutyrate, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4- hydroxybutyrate, gamma-butyrolactone, 1,4-butanediol, 4-hydroxybutanal, 4- hydroxybutyryl-CoA and/or putrescine or related products using the microbial organisms. (FIG. 1) |