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publicationDate 2016-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber MY-158648-A
titleOfInvention Compositions for modulating a kinase cascade and methods of use thereof
abstract THE INVENTION RELATES TO COMPOSITIONS COMPRISING 2-(5-(4-(2-MORPHOLINOETHOXY)PHENYL)PYRIDIN-2-YL)-N-BENZYLACETAMIDE AND ITS MESYLATE AND DIHYDROCHLORIDE SALTS. THE INVENTION PROVIDES AN EFFICIENT PROCESS FOR THE SYNTHESIS OF 2-(5-(4 -(2-MORPHOLINOETHOXY)PHENYL)PYRIDIN-2-YL)-N-BENZYLACETAMIDE AND ITS MESYLATE AND DIHYDROCHLORIDE SALTS AND METHODS FOR MODULATING ONE OR MORE COMPONENTS OF A KINASE CASCADE USING THE COMPOSITIONS OF THE INVENTION. THE PRESENT INVENTION ALSO PROVIDES A NOVEL POLYMORPH OF THE MESYLATE SALT OF 2-(5-(4-(2-MORPHOLINOETHOXY)PHENYL)PYRIDIN-2-YL)-N-BENZYLACETAMIDE (FORM A), CHARACTERIZED BY A UNIQUE X-RAY DIFFRACTION PATTERN AND DIFFERENTIAL SCANNING CALORIMETRY PROFILE, AS WELL AS A UNIQUE CRYSTALLINE STRUCTURE.
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