abstract |
THE PRESENT INVENTION RELATES TO COMBINATIONS BETWEEN ARTEMISININ-BASED POTENT ANTI-MALARIAL AGENTS, SELECTED FROM THE GROUP CONSISTING OF ART, DHA AND ARM, AND A FURTHER CHEMOTHERAPEUTIC DRUG SELECTED FROM THE GROUP CONSISTING OF A CAMPTOTHECIN DERIVATIVE, OR A PARP-1 INHIBITOR, OR AN INTERCALATING DNA AGENT, OR AN ALKYLATING AGENT. SUCH COMBINATIONS, SHOWED MEDIUM TO STRONG SYNERGISM IN VARIOUS MODELS OF CANCER, IN PARTICULAR IN NSCL. |