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publicationDate 2014-12-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber MY-153032-A
titleOfInvention Curcumin compounds with superior structural stability and processes for their preparation thereof
abstract ACCORDINGLY, THE INVENTION DISCLOSES COMPOUNDS WITH ENHANCED BIOAVAILABILITY FOR THE PREVENTION AND TREATMENT OF ANTI-HUMAN IMMUNODEFICIENCY VIRUS (HIV), ANTI-TUBERCULOSIS (TB), ANTI-ALZHEIMER OR ANTI-CANCER. THE INVENTION ALSO DISCLOSES THE METHOD IN SYNTHESIZING THESE COMPOUNDS WHEREIN THE STEPS INCLUDES MIXING CURCUMIN, ISATIN DERIVATIVES OR NINHYDRIN AND PROLINE IN 20 ML METHANOL. THE MIXTURE WAS THEN REFLUXED WITH A SOLVENT ON A WATER BATH AND EXCESS SOLVENT WAS REMOVED UNDER VACUUM. THE RESIDUE SUBJECTED TO FLASH COLUMN CHROMATOGRAPHY USING PETROLEUM ETHER: ETHYL ACETATE MIXTURE (4:1) AS ELUENT TO AFFORD THE PRODUCT. THE RATIO FOR CURCUMIN: ISATIN DERIVATIVE/NINHYDRIN: PROLINE IS 1:1:2 AND 1:2:4.
priorityDate 2011-01-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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