abstract |
THE INVENTION RELATES TO NOVEL PRODUCTS OF FORMULA (I): WHERE ---- IS A SINGLE OR DOUBLE BOND, RA = H, HAL, ALKOXY, O-CYCLOALKYL, HETEROARYL, PHENYL, NHCOALK, NHCOCYCLOALK OR NR1 R2; X = S, SO OR SO2; A = NH OR S; W = H, ALKYL OR COR WITH R = CYCLOALKYL; ALKYL, OPTIONALLY SUBSTITUTED WITH NR3R4, ALKOXY, HYDROXY, PHENYL, HETEROARYL, OR HETEROCYCLOALKYL; ALKOXY OPTIONALLY SUBSTITUTED BY NR3R4, IN OTHER WORDS A O-(CH2)N-NR3R4 GROUP, A O-PHENYL OR O-(CH2)N-PHENYL GROUP, WITH THE PHENYL OPTIONALLY SUBSTITUTED AND N= 1 TO 4; WHERE IN THE NR1 R2 GROUP; R1 = H OR ALK AND R2 = H, CYCLOALKYL OR ALKYL; R3 AND R4 = H, ALK, CYCLOALKYL, HETEROARYL OR PHENYL, R1, R2 AND/OR R3.R4 FORM A RING WITH N OPTIONALLY INCLUDING O, S, N AND/OR NH; ALL HETEROCYCLOALKYL, HETEROARYL AND PHENYL AND CYCLIC GROUPS BEING OPTIONALLY SUBSTITUTED, SAID PRODUCTS BEING IN ALL THE ISOMERIC FORMS AND ALL SALTS AS MEDICAMENTS IN PARTICULAR AS MET INHIBITORS. |