| abstract |
THE INVENTION RELATES TO A BIOCOMPATIBLE, AND NON-TOXIC POLYMER OF FORMULA (I), COMPRISING OF THREE MONOMERIC UNITS, SELECTED FROM 1-VINYLPYRROLIDONE (VP), N-ISOPROPYLACRYLAMIDE (NIPAM), AND ESTER OF MALEIC ANHYDRIDE AND POLYETHYLENE GLYCOL (MPEG), CROSS-LINKED WITH A BI-FUNCTIONAL VINYL DERIVATIVE, OF HIGH PURITY AND SUBSTANTIALLY FREE OF RESPECTIVE TOXIC MONOMERIC CONTAMINANTS, AND A PROCESS FOR PREPARATION THEREOF. THE INVENTION FURTHER RELATES TO NANOPARTICULATE PHARMACEUTICAL COMPOSITIONS OF POORLY WATER-SOLUBLE DRUGS OR COMPOUNDS COMPRISING THE POLYMER OF THE INVENTION, WHICH ARE SAFE, LESS-TOXIC AND CONVENIENT FOR BEDSIDE ADMINSTRATION TO PATIENTS IN NEED THEREOF. FURTHERMORE, THE INVENTION RELATES TO A HIGHLY SELECTIVE METHOD FOR PREPARATION OF NANOPARTICULATE PHARMACEUTICAL COMPOSITIONS OF POORLY WATER-SOLUBLE DRUGS OR COMPOUNDS. |