| abstract |
THE N-OXIDE FORMS, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND THE STEREOCHEMICALLY ISOMERIC FORMS THEREOF, WHEREIN N IS 1, 2, 3, OR 4; Z REPRESENTS O, S, NR 6, SO OR SO2; RL REPRESENT HYDROGEN, CYANO, HYDROXY, OR C1-4ALKYL OPTIONALLY SUBSTITUTED WITH HALO, R2 REPRESENTS HYDROGEN, C1-4ALKYL, OR C1-4ALKYLOXY-; R3 REPRESENTS HYDROGEN, C1-4ALKYL, C1-4ALKYLOXY- OR R3 COMBINED WITH R2 FORM TOGETHER A DIVALENT RADICAL SELECTED FROM THE GROUP CONSISTING OF -O-CH2- (A), -NR7-CH2- (B), -(CR8R9)M- (C) AND ?CR10= (D) WHEREIN M REPRESENTS 1OR 2 AND R7, R8, R9 AND R10 ARE EACH INDEPENDENTLY SELECTED FROM HYDROGEN OR C1-4ALKYL: R4 REPRESENTS HYDROGEN, HALO, HYDROXY, CYANO, AMINO, NR11R12, CL-4,ALKYLOXY- OPTIONALLY SUBSTITUTED WITH ONE OR WHERE POSSIBLE TWO OR THREE SUBSTITUENTS SELECTED FROM HYDROXY AND HALO OR R4 REPRESENTS C1-4ALKYL OPTIONALLY SUBSTITUTED WITH ONE OR WHERE POSSIBLE TWO OR THREE SUBSTITUENTS SELECTED FROM HYDROXY AND HALO: R5 REPRESENTS HYDROGEN, HALO, CYANO, AMINO, PHENYL, HYDROXY, CL-4ALKYLOXYCARBONYL, HYDROXYCARBONYL, NR13R14 OR C1-4ALKYL SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM HYDROXYCAIBONYL, PHENYL, C1-4ALKYLOXY OR NR15R16; R6 REPRESENTS HYDROGEN; R11 AND R12 EACH INDEPENDENTLY REPRESENT HYDROOEN, C1-4ALKYL OR C1-4ALKYLCARBONY1-; R13 AND R14 EACH INDEPENDENTLY REPRESENT HYDROOEN, C1-4ALKYL OR C1-4ALKYLCARBONY1-; R15 AND R16 EACH INDEPENDENTLY REPRESENT HYDROOEN, C1-4ALKYL OR C1-4ALKYLCARBONY1-; R17 AND R18 EACH INDEPENDENTLY REPRESENT HYDROOEN, C1-4ALKYL OR C1-4ALKYLCARBONY1-. |