| abstract |
OR_QANIC COMPOUND 5 THE INVENTION RELATED TO A NOVEL PROCESS, NOVEL PROCESS STEPS AND NOVEL INTERMEDIATES USEFUL IN THE SYNTHESIS OF PHARMACEUTICALLY ACTIVE COMPOUNDS, ESPECIALLY RENIN INHIBITORS, SUCH AS ALISKIREN. INTER ALIA, THE INVENTION RELATES TO A PROCESS FOR THE MANUFACTURE OF A COMPOUND OF THE FORMULA 11, R3 0 0 ORN"'---@ 4 H R 10 OR A SALT THEREOF, AND A COMPOUND OF FORMULA VI R3 0 0@ ):N@ I R4 ACT (VI) OR A SALT THEREOF, WHEREIN R' AND R 4AS WELL AS ACT ARE AS DEFINED IN THE SPECIFICATION, AND 15 PROCESSES OF MANUFACTURING THESE. ADDITIONALLY TRANSFORMATION OF COMPOUNDS (VI) WITH METALLO ORGANIC COMPOUNDS (VI]) GIVE RISE TO THE NEW COMPOUNDS (VILL) WHICH ARE DIRECT PRECURSORS FOR THE PREPARATION OF ALISKIREN. 20 |