| abstract |
-39- THIENO [3,2-DJ PYRIMIDINE DERIVATIVE USEFUL AS P13K INHIBITOR 5 ABSTRACT A TL-IIENOPYRIMIDINE OF FORMULA (1) AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF HAVE ACTIVITY AS INHIBITORS OF P13K WITH SELECTIVITY FOR THE PI I OA SUBTYPE, AND MAY BE USED TO TREAT DISEASES AND DISORDERS ARISING FROM ABNORMAL CELL GROWTH, FUNCTION OR 1 0 BEHAVIOUR, PARTICULARLY THOSE ASSOCIATED WITH P13 KINASE SUCH AS CANCER, IMMUNE DISORDERS, CARDIOVASCULAR DISEASE, VIRAL INFECTION, INFLAMMATION, METABOLISM/ENDOCRINE DISORDERS AND NEUROLOGICAL DISORDERS. PROCESSES FOR SYNTHESIZING THE COMPOUNDS ARE ALSO DESCRIBED. 2 0 |