| abstract |
PROCESS FOR THE PREPARATION OF DELMOPINOL AND DERIVATIVES THEREOF A PROCESS FOR THE PREPARATION OF DELMOPINOL (3-(4-PROPYLHEPTYL)-4-MORPHOLINETHANOL) OR A DERIVATIVE OR A PHARMACEUTICALLY ACCEPTABLE SALT, OR A SOLVATE THEREOF, INCLUDING AN HYDRATE, COMPRISES REACTING OXAZOLIDIN (2, 3-C] MORPHOLINE AND A GRIGNARD REAGENT, AND OPTIONALLY CONVERTING THE DELMOPINOL (OR DERIVATIVE) FREE BASE INTO A PHARMACEUTICALLY ACCEPTABLE SALT. THE OXAZOLIDIN [2, 3-CL MORPHOLINE AND THE GRIGNARD REAGENT ARE USEFUL AS INTERMEDIATES IN THE PRODUCTION PROCESS. |