| abstract |
THERE IS PROVIDED A MODIFIED RELEASE PHARMACEUTICAL COMPOSITION COMPRISING 4-(<3-[7-(3,3-DIMETHYL-2-OXOBUTYL)-9-OXA-3,7-DIAZABICYCLO-[3.3.1]NON-3-YL]PROPYL>AMINO)BENZONITRILE, TERT-BUTYL 2-<7-[3-(4-CYANO-ANILINO)PROPYL]-9-OXA-3,7-DIAZABICYCLO[3.3.1]NON-3YL>ETHYLCARBAMATE, TERT-BUTYL 2-<7-[4-(4-CYANOPHENYL)BUTYL]-9-OXA-3,7-DIAZABICYCLO[3.3.1]NON-3-YL>ETHYLCARBAMATE, OR TERT-BUTYL 2-<7-[(2S)-3-(4-CYANOPHENOXY)-2-HYDROXYPROPYL]-9-OXA-3,7-DIAZABICYCLO[3.3.1]NON-3-YL>ETHYLCARBAMATE, OR A PHARMACEUTICALLY-ACCEPTABLE SALT OF ANY OF THESE COMPOUNDS, IN PARTICULAR A GELLING POLYMER MATRIX MODIFIED RELEASE COMPOSITION. THE COMPOSITIONS ARE USEFUL IN THE PROPHYLAXIS AND/OR TREATMENT OF CARDIAC ARRHYTHMIAS. |