| abstract |
A PHARMACEUTICAL COMPOSITION COMPRISES, IN POWDER FORM, (A) AT LEAST ONE WATER-SOLUBLE THERAPEUTIC AGENT SELECTED FROM SELECTIVE COX-2 INHIBITORY DRUGS AND SALTS AND PRODRUGS THEREOF, FOR EXAMPLE PARECOXIB, IN A THERAPEUTICALLY EFFECTIVE TOTAL AMOUNT CONSTITUTING ABOUT 30TO ABOUT 90BY EIGHT, (B) A PARENTERALLY ACCEPTABLE BUFFERING AGENT IN AN AMOUNT OF ABOUT 5TO ABOUT 60BY WEIGHT, AND OPTIONALLY (C) OTHER PARENTERALLY ACCEPTABLE EXCIPIENT INGREDIENTS IN A TOTAL AMOUNT NOT GREATER THAN ABOUT 10BY WEIGHT, OF THE COMPOSITION. THE COMPOSITION IS RECONSTITUTABLE IN A PARENTERALLY ACCEPTABLE SOLVENT LIQUID TO FORM AN INJECTABLE SOLUTION. A LYOPHILIZATION PROCESS IS PROVIDED FOR PREPARATION OF SUCH A COMPOSITION. |