| abstract |
A COMPOUND OF THE FORMULA (FORMULA 1) WHEREIN A REPRESENTS:(FORMULA II)R REPRESENTS HYDROGEN OR METHYL; R1 AND R2 ARE INDEPENDENTLY HYDROGEN , OR C1-C4 ALKYL ; R3 AND R4 ARE INDEPENDENTLY HYDROGEN, C1-C4 ALKYL OR SAR, PROVIDED THAT AT LEAST ONE OF R3 AND R4 REPRESENTS SAR; AR REPRESENT A 5-OR 6-MEMBERED AROMATIC OR HETEROAROMATIC RING CONTAINING ZERO TO THREE NITROGEN ATOMS, ZERO OR ONE OXYGEN ATOM, AND ZERO OR ONE SULFUR ATOM OR AN 8-, 9- OR 10-MEMBERED FUSED AROMATIC OR HETEROAROMATIC RING SYSTEM CONTAINING ZERO TO FOUR NITROGEN ATOMS , ZERO TO ONE OXYGEN ATOM, AND ZERO TO ONE SULFUR ATOM WHICH MAY OPTIONALLY BE SUBSTITUTED WITH ONE OR MORE SUBSTITUENTS SELECTED FROM : HYDROGEN , HALOGEN , C1-C4 ALKYL, C2-C4 ALKENYL, C2-C4 ALKYNYL, ARYL, HETEROARYL , -CO2R5, -CN, -NO2, -NR6R7, -CF3,-OR8; R5, R6, R7, AND R8 ARE INDEPENDENTLY HYDROGEN , C1-C4 ALKYL, ARYL, HETEROARYL ,-C(O)R9, -C(O)NHR10, -C(O)R11, -SO2R12, OR, R6 AND R7 MAY TOGETHER BE (CH2)JQ(CH2)K WHERE Q IS O,S, NR13, OR, A BOND ; J IS 2 TO 7; K IS 0 TO 2; R9, R10, R11, R12, AND R13, ARE INDEPENDENTLY C1-C4 ALKYL, ARYL, OR HETEROARYL; OR AN ENANTIOMER THEREOF, AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF , PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE IN THERAPY , ESPECIALLY IN THE TREATMENT OR PROPHYLAXIS OF PSYCOTIC DISORDERS AND INTELLECTUAL IMPAIRMENT DISORDERS. |