| abstract |
THE PRESENT INVENTION DISCLOSES AND CLAIMS BENZIMIDAZOLE COMPOUNDS OF FORMULA (I): IN WHICH A IS ARYL OR HETEOARYL;R1 IS SELECTED FROM OPTIONALLY SUBSTITUED ALKYL,ALKOXY,ARYL OR HETEROARYL,NH-LOWER ALKYL OR NH-CYCLOALKYL,OR HALOGEN,NH2;1-IMIDAZOLYL OR SO2ME; R2 IS SELECTED FROM OPTIONALLY SUBSTITTUED –CO-ALKYL,-CO-CYCLOALKYL,-CO-ARALKYL,-CO-ARYL,-CO-ALKOXY,ARYL OR ARALKYL,OR –CO-AMINO,CO-NHR3 OR CO-R3R4 WHEREIN R3 AND R4 ARE SELECTED INDEPENDENTLY FROM HYDROGEN, ALKYL, HYDROXYALKYL, ALKOXYALKYL, FLUOROALKYL, ALKYNYL, HETEROALKYL, ALKYLHETEROALKYL,ARYL,ARALKYL OR TOGETHER FORM AN ALKYLENE CHAIN OPTIONALLY CONTAINING ONE TO 4 HETEROATOMS;A PHARMACEUTICALLY ACCEPTABLE SALT OR A PRODRUG THEREOF;THE USE COMPOUNDS OF FORMULA (I) FOR THE TREATMENT OF CANCER,AND PHAMACEUTICAL COMPOSITIONS COMPRISING A COMPOUND OF FORMULA (I) AND ONE OR MORE PHARMACEUTICALLY ACCEPTABLE ADJUVANTS OR DILUENTS. |