| abstract |
A BIOADHESIVE COMPOSITION WHEREIN THE ACTIVE INGREDIENT MAY BE PROTECTED FROM WATER OR THE SURROUNDING ENVIRONMENT, TEHREBY PROTECTING IT FROM METABOLISM OR FROM OTHER DEGRADIATION CAUSED BY MOISTURE , ENZYMES, OR pH EFFECTS, ADN MAKING IT BIOAVAILABLE ONLY AT A CONTROLLED RATE. THE ACTIVE INGREDIENT MAY BE PROTECTED FROM MOISTURE DURING THE MANUFACTURING PROCESS AND MORE IMPORTANTLY MAY BE PROTECTED FROM MOISTURE AND THE IMMEDIATE SEPTIC ENVIRONMENT UNTIL AFTER TEH PATIENT HAS APPLIED TEH COMPOSITION, AND THEN ONLY AT A SLOW AND CONTROLLED RATE. IT IS BY THIS PROCESS OF PROGRESSIVE HYDRATION THAT THE ACTIVE INGREDIENT REMAINS PROTECTED FOR MANY HOURS AFTER ADMINISTRATION. IT IS ALSO BY THE PROCESS OF PROGRESSIVE HYDRATION THAT CONTROLLED AND SUSTAINED RELEASE IS ACHIEVED BECAUSE ONLY THAT PART OF THE ACTIVE INGREDIENT THAT IS THE HYDRATED (AQUEOUS) FRACTION OF THE COMPOSITION IS AVAILABLE FOR ABSORPTION (BIOAVAILABLE). |