| abstract |
A COMPOUND OF THE FORMULA WHEREIN Q IS AS DEFINED ABOVE, ARE USEFUL IN THE TREATMENT OF A CONDITION SELECTES FROM THE GROUP CONSISTING OF ARTHRITIS (INCLUDING OSTEARTHRITIS AND RHEUMATOID ARTHRITIS), INFLAMMATORY BOWEL DISEASE, CROHN''S DISEASE, EMPHYSEMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ALZHEIMER''S DISEASE, ORGAN TRANSPLANT TOXICITY, CACHEXIA, ALLERGIC REACTIONS, ALLERGIC CONTACT HYPERSENSITIVITY, CANCER, TISSUE ULCERATION, RESTENOSIS, PERIODONTAL DISEASE, EPIDERMOLYSIS BULLOSA, OSTEOPOROSIS, LOOSENING OF ARTIFICIAL JOINT IMPLANTS, , ATHEROSCLEROSIS (INCLUDING ATHEROSCLEROTIC PLAQUE RUPTURE, AORTIC ANEURYSM 9INCLUDING ABDOMINAL AORTIC ANEURYSM AND BRAIN AORTIC ANEURYSM), CONGESTIVE HEART FAILURE, MYOCARDIAL INFARCTION, STROKE, CEREBRAL ISCHEMIA, HEAD TRAUMA, SPINAL CORD INJURY, NEURO-DEGENERATIVE DISORDERS (ACUTE AND CHRONIC), AUTOIMMUNE DISORDERS, HUNTINGTON''S DISEASE, PARKINSON''S DISEASE, MIGRAINE, DEPRESSION, PERIPHERAL NEUROPARHY, PAIN, CEREBRAL AMYLOID ANGIOPATHY, NOOTROPIC OR COGNITION ENHANCEMENT AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, OCULAR ANGIOGENESIS , CORNEAL INJURY, MACULAR DEGENERATION, ABNORMAL WOUND HEALING, BURNS, DIABETES, TUMOR INVASION, TUMOR GROWTH, TUMOR METASTASIS, COMEAL SCARRING, SCLERITIS, AIDS, SEPSIS AND SEPTIC SCHACK. IN ADDITION, THE COMPOUNDS OF THE PRESENT INVENTION MAY BE USED IN COMBINATION THERAPY WITH STANDARD NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID''S) AND ANALGESICS, AND IN COMBINATION WITH CYTOTOXICDRUGS SUCH AS ADRIAMYCIN, DAUNOMYCIN, CIS-PLATINUM, ETOPOSIDE, TAXOL, TAXOTERE AND OTHER ALKALOIDS, SUCH AS VINCRISTINE, IN THE TREATMENT OF CANCER. |