| abstract |
THE PRESENT INVENTION PROVIDES NOVEL COMPOUNDS OF FORMULA( FORMULA 1 )THE N-OXIDES, THE STEREOCHEMICALLY ISOMERIC FORMS THEREOF, AND THE PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, WHEREIN A AND B TAKEN TOGETHER FORM A BIVALENT RADICAL OF FORMULA :-N=CH- (A), -CH=N- (B), -CH2-CH2- (C), -CH=CH- (D), -C(=O)-CH2- (E), -CH2-C(=O)- (F); R1 IS HYDROGEN, C1-6ALKYL, OR HALO; R2 IS HYDROGEN OR HALO; R3 IS HYDROGEN; C1-8ALKYL; C3-6CYCLOALKYL OR C1-8ALKYL SUBSTITUTED WITH HYDROXY, OXO, C3-6CYCLOALKYL OR ARYL. HET IS FIVE- OR SIX-MEMBERED OPTIONALLY SUBSTITUTED HETEROCYCLIC RING. THE USE AS A MEDICINE, ESPECIALLY AS A LIPID LOWERING AGENT IS DISCLOSED AS WELL AS PHARMACEUTICAL COMPOSITIONS AND PROCESSES FOR PREPARING COMPOUNDS AND COMPOSITIONS. |