| abstract |
THE INVENTION IS CONCERNED WITH THE COMPOUNDS HAVING THE FORMULA ( FORMULA 1 ) THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS AND THE STEREOCHEMICALLY FORMS THEREOF, WHEREIN Y IS CH OR N; R1, R2 AND R3 EACH INDEPENDENTLY ARE HYDROGEN OR C1-4ALKYL; R4 AND R5 EACH INDEPENDENTLY ARE HYDROGEN, HALO, C1-4ALKYL, C1-4ALKYLOXY, HYDROXY, TRIFLUOMETHYL, TROFLUOROMETHYLOXY OR DIFLUOROMETHYLOXY; R6 IS HYDROGEN; OR R6 IS PHENYL OPTIONALLY SUBSTITUTED WITH HALO; PYRIDNYL; FURANYL; THIENYL; 3-CHLORO-BENZO[B[THIEN-2-YL; TRIFUOROMETHYL; C1-4ALKYLOXYCARBONYL; DIHALOPHENYLCYCLOPROPANYL; C3-6CYCLOALKYL; ADAMANTYL; C2-6ALKENYL OPTIONALLY SUBSTITUTED WITH HALOPHENYL; OR C1-4ALKYL OPTIONALLY SUBSTITUTED WITH HALO, PHENYL, HALOPHENYL, DIHALOPHENYL, PHENYLOXY, PIPERIDINYL, PYRROLIDINYL, C1-4ALKYLPIPERAZINYL, C1-4ALKYL-CARBONYLPIPERAZINYL, C1-4ALKYLOXYCARBONYLPIPERAZINYL, PHTHALIMINO, AMINO, MONO- OR DI(C1-20)ALKYLAMINO OR C3-6CYCLOALKYLAMINO; Z IS C=O OR CHOH; AND A IS RADICAL OF FORMULA( FORMULA A1, A2, A3, A4, A5, A6, A7)COMPOSITIONS COMPRISING SAID COMPOUNDS, PROCESS FOR PREPARING THE SAME AND THE USE OF THESE COMPOUNDS AS A MEDICINE. |