| abstract |
A [N ARALKYL- SUBSTITUTED INDOLE] COMPOUD OF THE FORMULA (FORMULA 1) IN WHICH R1, R3, R4, AND R6, ARE OPTIONAL SUBSTITUENTS; R2 IS HALO, NITRILE, AN OPTIONALLY PROTECTED ACID GROUP OR -CONR7R8 WHERE R7 AND R8 ARE EACH HYDROGEN OR C1-4 ALKYL; R5 IS [A HETEROARYL GROUP] (FORMULA 2) WHERE W IS -CH=CH, -CH=N-, -N=CH-,-O- OR -S-, R9 IS HYDROGEN, HALO,C1-C4 ALKYL, C1-4 ALKOXY OR TRIHALOMETHYL, AND R10 HYDROGEN, C1-4 ALKYL, C2-6 ALKENYL, C3-6 CYCLOALKYL OR C1-4 ALKYL-C3-6 CYCLOALKYL; AND X AND Y ARE ALKYLENEOXY, ALKYLENE OR ALKENYLENE. THE COMPOUNDS IN UNPROTECTED FORM ARE ACTIVE AS LEUKOTRIENE ANTAGONISTS. |