| abstract |
NOVEL 5'-DEOXY-CYTIDINE DERIVATIVES REPRESENTED BY THE GENERAL FORMULA (I) WHEREIN R1IS A HYDROGEN ATOM OR A GROUP EASILY HYDROLYZABLE UNDER PHYSIOLOGICAL CONDITIONS; R2 IS A HYDROGEN ATOM, OR -CO-OR4 GROUP [WHEREIN R4 IS A SATURATED OR UNSATURATED, STRAIGHT OR BRANCHED HYDROCARBON GROUP CONSISTING OF ONE TO FIFTEEN CARBON ATOMS, OR A GROUP OF THE FORMULA -(CH2)N –Y (IN WHICH Y IS CYCLOHEXYL OR PHENYL; N IS AN INTEGER FROM 0 TO 4)]; R3 IS A HYDROGEN ATOM, BROMO, IODO, CYANO, A C1-4 ALKYL GROUP [WHICH MAY BE SUBSTITUTED WITH HALOGEN ATOM(S)], A VINYL OR ETHYNYL GROUP [WHICH MAY BE SUBSTITUTED WITH HALOGEN ATOM(S), C1-4 ALKYL, CYCLOALKYL, ARALKYL, OR AROMATIC RING WHICH MAY HAVE ONE OR MORE HETERO ATOM(S)], OR AN ARALKYL GROUP WHICH MAY BE SUBSTITUTED FOR USE IN MEDICAL THERAPY, ESPECIALLY TUMOR THERAPY. |