| abstract |
THIS INVENTION CONCERNS THE USE OF THE COMPOUNDS OF FORMULA (FORMULA I)THE N-OXIDES, THE PHARMACEUTICALLY ACCEPTABLE ADDITION SALTS, QUATERNARY AMINES AND THE STEREOCHEMCALLY ISOMERIC FORMS THEREOF, WHEREIN -A1=A2-A3=A4- FORMS A PHENYL, PYRIDINYL, PYRIMIDINYL, PYRIDAZINYL OR PYRAZINYL WITH THE ATTACHED VINYL GROUP; N IS 0 TO 4; AND WHERE POSSIBLE 5; R1 IS HYDROGEN, ARYL, FORMYL, C1-6ALKYLCARBONYL, C1-6ALKYL, C1-6ALKYLOXYCARBONYL OR SUBSTITUTED C1-6ALKYL; EACH R2 INDEPENDENTLY IS HYDROXY, HALO, OPTIONALLY SUBSTITUTED C1-6ALKYL, C2-6ALKENYL OR C2-6ALKYLNYL, C3-7CYCLOALKYL, C1-6ALYLOXY, C1-6ALKYLOXYCARBONYL, CARBOXYL, CYANO, NITRO, AMINO, MONO- OR DI(C1-6ALKYL)AMINO, POLYHALOMETHYL, POLYHALOMETHYLOXY, POLYHALOMETHYLTHIO, -S(=O)PR4, -NH(=O)PR4, -C(=O)R4, -NHC(=O)H, -C(=O)NHNH2, -NHC(=O)R4, -C(=NH)R4 OR A 5-MEMBERED HETEROCYCLIC RING; P IS 1 OR 2; L IS OPTIONALLY SUBSTITUTED C1-10ALKYL, C2-10ALKENYL, C2-10ALKYNYL OR C3-7CYCLOALKYL; OR L IS -X-R3 WHEREIN R3 IS OPTIONALLY SUBSTITUTED PHENYL, PYRIDINYL, PYRIMIDINYL, PYRAZINYL OR PYRIDAZINYL; X IS -NR1-, -NH-NH-, -N=N-, -O-, -C(=O)-, -CHOH-, -S-, -S(=O)- OR -S(=O)2-; ARYL IS OPTIONALLY SUBSTITUTED PHENYL; FOR THE MANUFACTURE OF A MEDICINE FOR THE TREATMENT OR SUBJECTS SUFFERING FROM HIV (HUMAN IMMUNODEFIENCY VIRUS) INFECTION. |