| abstract |
A PYRIDINE DERIVATIVE REPRESENTED BY THE FORMULA (1):[ WHEREIN R¹ REPRESENTS A HALOGEN ATOM OR A HALOGEN-SUBSTITUTED LOWER ALKYL; R² AND R³ RESPECTIVELY REPRESENT A HYDROGEN ATOM OR A HALOGEN ATOM;V REPRESENTS A GROUP: -C( =O ) NH-, -NHC ( =O ) OR NH-; AND A REPRESENTS A¹, A² OR A³:(GROUPS IN A¹ TO A³ RESPECTIVELY REPRESENT A HYDROGEN ATOM, A LOWER ALKYL, A LOWER ALKANOYL, HYDROXYL, BENZOYL OR AN OXO GROUP)] OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF. THE COMPOUND (1) INHIBITS COLLAGEN PRODUCTION AND IS USEFUL FOR PREVENTIVE OR TREATING FIBROSIS. |