| abstract |
A COMPOUND OF FORMULA (I) WHEREIN R1, R2 AND Q ARE AS DEFINED ABOVE, USEFUL IN THE TREATMENT OF A CONDITION SELECTED FROM THE GROUP CONSISTING OF ARTHRITIS, CANCER, TISSUE ULCERATION, MACULAR DEGENERATION, RESTENOSIS, PERIODONTAL DISEASE, EPIDERMOLYSIS BULLOSA, SCLERITIS, AND OTHER DISEASES CHARACTERIZED BY MATRIX METALLOPROTEINASE ACTIVITY, AIDS, SEPSIS, SEPTIC SHOCK AND OTHER DISEASES INVOLVING THE PRODUCTION OF TNF. IN ADDITION, THE COMPOUNDS OF THE PRESENT INVENTION MAY BE USED IN COMBINATION THERAPY WITH STANDARD NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAID'S) AND ANALGESICS, AND IN COMBINATION WITH CYTOTOXIC DRUGS SUCH AS ADRIAMYCIN, DAUNOMYCIN, CIS-PLATINUM, ETOPOSIDE, TAXOL, TAXOTERE AND OTHER ALKALOIDS, SUCH AS VINCRISTINE, IN THE TREATMENT OF CANCER. |