http://rdf.ncbi.nlm.nih.gov/pubchem/patent/MY-119697-A
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65583 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-59 |
filingDate | 1999-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62a0fa984b3ff70976d59b2fec95d396 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fc0c74b635f2592ce500afa1565993d |
publicationDate | 2005-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | MY-119697-A |
titleOfInvention | Process for preparing tricyclic compounds having antihistaminic activity |
abstract | DISCLOSED IS A PROCESS FOR PREPARING A COMPOUND HAVING THE FORMULA:WHEREIN R1 IS SELECTED FROM THE GROUP CONSISTING OF: ALKYL, ALKENYL, ALKYNYL, ARYL, ARALKYL, CYCLOALKYL, AND CYLOALKYLALKYL, R1 BEING OPTIONALLY SUBSTITUTED BY SUBSTITUENTS SELECTED FROM HALO, -OH, ALKYL, ALKOXY, OR-CF3, SAID PROCESS COMPRISING THE FOLLOWING STEPS:(A) REACTING A KETONE HAVING THE FORMULAWITH A CARBANION HAVING THE FORMULAWHEREIN R1 IS AS DEFINED ABOVE, AND R2 AND R3 ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF -OR(A) AND -R(A), WHEREIN R(A) IS ALKYL, PHENYL, SUBTITUTED PHENYL, CYCLOALKYL, SUBSTITUTED CYLOALKYL, CYCLOALKYLALKYL, OR SUBSTITUTED CYCLOALKYLALKYL;(B) TREATING THE REACTION MIXTURE FROM STEP (A) WITH A PROTONATING AGENT TO FORM A ß-HYDROXY INTERMEDIATE HAVING THE FORMULA WHEREIN R1, R2 AND R3 ARE AS DEFINED ABOVE; AND(C) THERMALLY DECOMPOSING THE ß-HYDROXY INTERMEDIATE TO FORM THE COMPOUND OF FORMULA (I). THE COMPOUNDS MADE BY THIS PROCESS HAVE ANTIHISTAMIC ACTIVITY, E.G., LORATADINE. ALSO DISCLOSED IS A PROCESS FOR PREPARING DESCARBOETHOXYLORATADINE, BY CARRYING OUT THE PROCESS ABOVE, AND CONVERTING THE PRODUCT TO DESCARBOETHOXYLORATADINE. ALSO DISCLOSED ARE NOVEL INTERMEDIATES HAVING THE FORMULAWHEREIN R1, R2 AND R3 ARE AS DEFINED ABOVE. |
priorityDate | 1998-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.