| abstract |
INHIBITORS FOR MATRIX METALLOPROTEASES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND A PROCESS FOR USING THEM TO TREAT A VARIETY OF PHYSIOLOGICAL CONDITIONS. THE COMPOUNDS OF THE INVENTION HAVE THE GENERALIZED FORMULA (FORMULA 1) WHEREIN R1 REPRESENTS C6-C12 ALKYL; C5-C12 ALKOXY; C5-C12 ALKYLTHIO; A POLYETHER OF FORMULA R2O(C2H4O)A- IN WHICH A IS 1 OR 2 AND R2 IS C1-C5 ALKYL, PHENYL, OR BENZYL; AND SUBSTITUTED ALKYNYL OF FORMULA R3(CH2)B-C( )C-; IN WHICH B IS 1-10 AND R3 IS H-, HO-, OR R4O- IN WHICH R4 IS C1-C3 ALKYL, PHENYL, OR BENZYL. THE ALKYL, PHENYL, AND BENZYL PORTIONS OF R1 MAYBEAR AT LEAST ONE PHARMACEUTICALLY-ACCEPTABLE SUBSTITUENT. THE SUBSCRIPT N IS 2-4. R5 REPRESENTS PHENYL; IMIDOYL OF 4-12 CARBON ATOMS; (3H)-BENZO-1, 2, 3-TRIAZIN-4-ON-3-YL; N-SACCHARINYL; (2H)-PHTHALAZIN-1-ON-2-YL; 2-BENZOXAZOLIN-2-ON-3-YL; 5, 5-DIMETHYLOXAZOLIDINE-2, 4-DION-3-YL; AND THIAZOLIDINE-2, 4-DION-3-YL; WITH THE PHENYL AND BENZO PORTIONS OF R5 PERMISSIBLY BEARING AT LEAST ONE PHARMACEUTICALLY-ACCEPTABLE SUBSTITUENT. PHARMACEUTICALLY ACCEPTABLE SALTS OF THESE MATERIALS ARE ALSO INCLUDED. |