| abstract |
THIS INVENTION IS RELATING TO NEW ESTRA-1, 3, 5(10)-TRIEN-SULFAMATES CARRYING AT THE 3-POSITION AN R-SO2-O-GROUP, WITH R BEING AN R1R2N-GROUP IN WHICH R1 AND R2, INDEPENDENTLY OF EACH OTHER, REPRESENT A HYDROGEN ATOM, AN ALKYL RESIDUE WITH 1-5 C ATOMS OR, TOGETHER WITH THE N ATOM, A POLYMETHYLENE-IMINO RESIDUE WITH 4-6 C ATOMS OR A MORPHOLINO RESIDUE. THE COMPOUNDS, ACCORDING TO THIS INVENTION, ARE SUITABLE FOR HORMONAL CONTRACEPTION AND CLIMACTERIC HORMONE REPLACEMENT THERAPY (HRT) AS WELL AS FOR TREATMENT OF GYNECOLOGICAL AND ANDROLOGICAL DISEASES. HENCE, ONLY LOW HEPATIC ALSO DESCRIBED ARE PROCESSES FOR PREPARATION OF THE COMPOUNDS ACCORDING TO THIS INVENTION AND FOR PREPARATION OF PHARMACEUTICAL COMPOSITIONS. |