| abstract |
A TRANSDERMAL THERAPEUTIC SYSTEM FOR THE ADMINISTRATION OF PHYSOSTIGMINE TO THE SKIN, CONSISTING OF A BACKING IMPERMEABLE TO ACTIVE SUBTANCE, A PRESSURE-SENSITIVE RESERVOIR LAYER CONTAINING 40 TO 90WT. POLYMERIC MATERIAL AND 0.1 TO 20WT.PHYSOSTIGMINE BASE OR ONE OF THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, AND OF A PROTECTIVE LAYER COVERING THE RESERVOIR LAYER, COMPRISES IN ITS RESERVOIR LAYER ACRYLATE- OR METHACRYLATE-BASED POLYMERIC-BASED MATERIAL AND 0.1 TO 40WT. OF A SOFTENER CONTAINING THE HYDROXYL GROUP WITH AN HLB VALEU BETWEEN 1.1 AND 12.0. |