| abstract |
A PHARMACEUTICAL COMPOUND OF THE FORMULA:@@FORMULA 1@@IN WHICH N IS 0, 1 OR 2 AND R1 IS ATTACHED AT ANY OF THE POSITIONS 5, 6, 7, 8, 9, OR 10, AND EACH R1 IS HALO, TRIFLUOROMETHYL, C1-4 ALKOXY, HYDROXY, NITRO, C1-4 ALKYL, C1-4 ALKYLTHIO, HYDROXY-C1-4 ALKYL, HYDROXY-C1-4 ALKYL, HYDROXY-C1-4ALKOXY, TROFLUOROMETHOXY, CARBOXY, -COOR5 WHERE R5 IS AN ESTER GROUP, -CONR6R7 OR -NR6R7 WHERE R6 AND R7 ARE EACH HYDROGEN OR C1-4 ALKYL;@@R2 IS PHENYL, NAPHTHYL OR HETEROARYL SELECTED FROM THIENYL, PYRIDYL, BENZOTHEINYL, QUINOLINYL, BENZOFURANYL OR BENZIMIDAZOLYL, SAID PHENYL, NAPHTYL AND HETEROARYL GROUPS BEING OPTIONALLY SUBSTITUTED, OR R2 IS FURANYL OPTIONALLY SUBSTITUTED WITH C1-4; ALKYL;@@R3 IS NITRILE, CARBOXY, -COOR8 WHERE R8 IS AN ESTER GROUP, -CONR9R10 WHERE R9 AND R10 ARE EACH HYDROGEN OR C1-4ALKYL, OR R11SO2- WHERE R11 IS C1-4 ALKYL OR OPTIONALLY SUBSTITUTED PHENYL; AND@@R4 IS -NR12R13, -NHCOR12, -N(COR12)2 OR -N=CHOCH2R12 WHERE R12 AND R13 ARE EACH HYDROGEN OR C1-4 ALKYL OPTIONALLY SUBSTITUTED WITH CARBOXY,@@WHERE X IS C2-4 ALKYLENE, OR -NHSO2R14 WHERE R14 IS C1-4 ALKYL OR OPTIONALLY SUBSTITUTED PHENYL; PROVIDED THAT WHEN N IS 0, R4 IS NITRILE AND R4 IS -NH2, R2 IS NOT PHENYL OR PHENYL SUBSTITUTED IN THE PARA-POSITION WITH A SINGLE CHLORO, HYDROXY OR METHOXY SUBSTITUENT;@AND SALT THEREOF.@ |