| abstract |
CONJUGATE USEFUL FOR TREATING GASTROINTESTINAL TUMOURS SUCH AS COLORECTAL TUMOURS COMPRISES AN ANTIBODY SUCH AS C242 ANTIBODY AND A TOXIN SUCH AS RICIN A. THE ANTIBODY AND TOXIN MAY BE COUPLED BY A LINKER. PREFERRED CONJUGATES ARE THOSE OF FORMULA (H) A-S1-S2-X-CON-B; WHEREIN A COMPRISES RECOMBINANT RICIN A, AND B COMPRISES A TARGET CELL BINDING MOIETY WHICH COMPRISES C242 ANTIBODY;S1 IS A SULPHUR ATOM PRESENT ON RECOMBINANT RICIN A;THE NH IS ON THE C242 ANTIBODY;S2 IS A SULPHUR ATOM GROUP AND X A STRAIGHT CHAIN (1-6C) ALKYL GROUP, OPTIONALLY SUBSTITUTED BY ONE OR TWO SUBSTITUENTS SELECTED FROM (1-6C) ALKYL, PHENYL AND (1-4C) ALKYLPHENYL; OR AN (1-4C) ALKYLPHENYL GROUP, IN WHICH THE ALKYL MOIETY IS OPTIONALLY SUBSTITUTED BY ONE OR TWO SUBSTITUENTS SELECTED FROM (1-6C) ALKYL, PHENYL AND (1-4C) ALKYLPHENYL; AND WHEREIN THE PHENYL RING MAY BEAR A SUBSTITUENT SELECTED FROM HALOGEN, (1-4C) ALKYL AND (1-4C) ALKOXY. |