| abstract |
4-AMINO-2-(4-N-PROPYLPIPERAZIN-1-YL)-5-(2,3,5-TRICHLOROPHENYL) PYRIMIDINE AND ACIS ADDITION SALTS THEREOF ARE INHIBITORS EXTRACELLULAR GLUTAMATE RELEASE. THEY HAVE NEGLIGIBLE EFFECT AGAINST THE ENZYME DIHYDROFOLATE REDUCTASE. THEY ARE USEFUL IN THE PROPHYLAXIS IN A MAMMAL OF A NEUROGENERATIVE OR OTHER NEUROLOGICAL DISORDER OF THE CENTRAL NERVOUS SYSTEM, THE AETIOLOGY OF WHICH INCLUDES EXCESSIVE RELEASE OF NEUROTRANSMITTER GLUTAMATE. |