| abstract |
COMPOUNDS OF THE FORMULA (FORMULA 1) X IS O, NH, OR S; A, B, D, E, AND F ARE EACH INDEPENDENTLY C, N, O, OR S; THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF. THESE COMPOUNDS ARE USEFUL PSYCHOTHERAPEUTICS AND ARE POTENT SEROTONIN (5-HT1) AGONISTS AND MAY BE USED IN THE TREATMENT OF DISPRESSION, ANXIETY, EATING DISORDERS, OBESITY, DRUG ABUSE, CLUSTER HEADACHE, MIGRAINE, PAIN, CHRONIC PAROXYSMAL HEMICRANIA AND HEADACHE ASSOCIATED WITH VASCULAR DISORDERS, AND OTHER DISORDERS ARISING FROM DEFICIENT SEROTONERGIC NEUROTRANSMISSION. THE COMPOUNDS CAN ALSO BE USED AS CENTRALLY ACTING ANTIHYPERTENSIVES AND VASODILATORS. |