abstract |
A PROCESS FOR PREPARING A COMPOUNDS OF THE FORMULA (FORMULA 1) OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF, WHICH COMPRISES REACTING A PIPERAZINE OF THE FORMULA (FORMULA 2) WITH AN ALKYL HALIDE CONTAINING COMPOUND OF THE FORMULA (FORMULA 3) IN WATER WITH A REAGENT TO NEUTRALIZE THE HYDROHALIC ACID AND HEATING THE MIXTURE UNDER CONDITIONS WHICH ARE SUITABLE TO EFFECT THE COUPLING OF SAID PIPERAZINE WITH SAID ALKYL HALIDE CONTAINING COMPOUND. |