| abstract |
THE INVETION RELATES TO NOVEL, ANTIHYPOXYCALLY ACTIVE 2-OXO-3, 8-DIAZASPIRO [4,5]DECANE DERIVATIVES OF THE FORMULA (I) (FORMULA 1) WHEREIN R MEANS HYDROGEN, A C1-12 ALKYL, C3-6 CYCLOALKYL, CARBOCYCLIC C6-10 ARYL OR CARBOCYCLIC C6-10 ARYL-C1-4 ALKYL GROUP, THE TWO LATTER ONES OPTIONALLY BEING SUBSTITUTED ON THEIR AROMATIC PART; ONE OF R1 AND R2 STANDS FOR A HYDROXYL GROUP WHEREAS THE OTHER MEANS A METHYL GROUP; R3 AND R4, WHICH ARE THE SAME OR DIFFERENT, REPRESENT HYDROGEN, ONE OR MORE HALOGEN (S), C1-4 ALKYL, C1-4 ALKOXY, TRIHALOMETHYL GROUP OR A HYDROXYL GROUP OPTIONALLY ESTERIFIED BY A C1-4 ALKANOIC ACID; AND N IS 1 OR 2, THEIR ISOMERS, SOLVATES, HYDRATES, ACID ADDITION AND QUARTENARY AMMONIUM SALTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS. |