abstract |
PIPERIDINYL, PYRROLIDINYL, AZEPINYL AND PIPERAZINYL PYRIDAZINES OF FORMULA WHEREIN ONE OR TWO CARBON ATOMS OF THE MOIETY MAY BE SUBSTITUTED WITH C1-4 ALKYLOXY OR TWO CARBON ATOMS OF THE CH2 GROUPS OF SAID MOIETY MAY BE BRIDGED WITH A C2-4 ALKANEDIYL RADICAL; X REPRESENTS CH OR N: R1 REPRESENTS HYDROGEN C1-4 ALKYL, HALO, HYDROXY, TRIFLUOROMETHYL, CYANO, C1-4 ALKYLOXY, C1-4 ALKYLTHIO, C1-4 ALKYLSULFINYL, C1-4 ALKYLSULFONYL, C1-4 ALKYLOXYCARBONYL, C1-4 ALKYLCARBONYL OR ARYL: R1 AND R3 EACH INDEPENDENTLY REPRESENT HYDROGEN OR C1-4 ALKYL: ALK REPRESENTS C1-4 ALKANEDIYL; R4 AND R5 EACH INDEPENDENTLY REPRESENT HYDROGEN C1-4 ALKYL OR HALO, AND HET REPRESENTS THE ADDITION SALTS AND STEREOCHEMICALLY ISOMERIC FORMS THEREOF, SAID COMPOUNDS HAVING ANTIPICORNIVIRAL ACTIVITY. PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AS ACTIVE INGREDIENT, AND A METHOD OF PREPARING SAID COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS. |