| abstract |
COMPOUNDS OF THE FORMULA (FORMULA 1) WHEREIN THE BROKEN LINE REPRESENTS AN OPTIONAL DOUBLE BOND; X IS 0, S ,CH2 OR CH2CH2; R1 IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, C1-C6 ALKOXY,C1-C6 ALKANOYL, C1-C6 ALKYL, AND C1-C6 ALKYL SUBSTITUTED WITH 1,2 OR 3 HALOGEN ATOMS; R2 IS SELECTED FROM THE GROUP CONSISTING OF PHENYL, SUBSTITUTED PHENYL, HETEROCYCLIC GROUPS AND SUBSTITUTED HETEROCYCLIC GROUPS; R3 AND R4 ARE INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, HALOGEN, C1-C6 ALKYL, OR TRIFLUOROMETHYL, OR R3 AND R4, TAKEN TOGETHER WITH THE CARBON ATOMS TO WHICH THEY ARE ATTACHED, FORM A SIX-MEMBERED CARBOCYCLIC AROMATIC RING AND THE PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF. THE COMPOUNDS ARE USEFUL IN TREATING INFLAMMATION OR OTHER PROSTAGLANDIN OR LEUKOTRIENE MEDIATED DISEASES. |