| abstract |
HYPOGLYCEMIC THIAZOLIDINE-2,4-DIONE DERIVATIVES (FORMULA 1) WHEREIN THE DOTTED LINE REPRESENTS A BOND OR NO BOND; V IS -CH=CH-, -N=CH-, -CH=N- OR S;W IS CH2, CHOH, CO, C=NOR OR -CH=CH-; X IS S, O,NR1, -CH=N- OR -N=CH-; Y IS CH OR N; Z IS HYDROGEN, (C1-C7)ALKYL, (C3-C7)CYCLOALKYL, PHENYL, NAPHTHYL, PYRIDYL, FURYL, THIENYL OR PHENYL MONO- OR DISUBSTITUTED WITH THE SAME OR DIFFERENT GROUPS WHICH ARE (C1-C3)ALKYL, TRIFLUOROMETHYL, (C1-C3)ALKOXY, FLUORO, CHLORO OR BROMO; Z1 IS HYDROGEN OR (C1-C3)ALKYL; R IS HYDROGEN OR METHYL; AND N IS 1, 2 OR 3; A PHARMACEUTICALLY ACCEPTABLE CATIONIC SALT THEREOF; OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT THEREOF WHEN THE COMPOUND CONTAINS A BASIC NITROGEN. |