abstract |
1- R"- 3- Q- 4- R''- 5- R-1, 6- NAPHTHYRIDIN- 2 (1H)- ONES (1) OR SALTS THEREOF, WHERE R IS LOWER- ALKYL, R'' IS HYDROGEN OR METHYL, R" IS HYDROGEN OR LOWER ALKYL, AND Q IS HYDROGEN, HYDROXY, AMINO, CYANO, CARBAMYL, CARBOXY OR AMINOCARBAMYL, ARE USEFUL AS CARDIOTONIC AGENTS ( I, Q IS HYDROGEN, HYDROXY, AMINO, CYANO OR CARBAMYL ) AND/OR INTERMEDIATES THEREFOR ( I, Q IS CARBOXY, AMINOCARBAMYL, HYDROGEN, AMINO, CYANO OR CARBAMYL ). ALSO SHOWN ARE 3- Q''- 4-R''- 5- (RCO)- 6- [ 2-( DI- LOWER- ALKYLAMINO ) ETHENYL ]- 2(I H)- PYRIDINONES (II) OR SALTS THEREOF, WHERE R AND R'' ARE AS ABOVE AND Q'' IS HYDROGEN OR CYANO, WHICH ARE USEFUL AS CARDIOTONICS (II, Q'' IS HYDROGEN) AND/OR INTERMEDIATES (II,Q'' IS CYANO OR HYDROGEN). PROCESSES FOR PREPARING THE COMPOUNDS OF FORMULAS 1 AND II ARE SHOWN. |