| abstract |
AN ANTITUMOR AGENT COMPRISING (i) AT LEAST PYRIMIDINE TYPE NUCLEIC ACID DERIVATIVE HAVING THE GENERAL FORMULA (1):(FORMULA 1) WHEREIN X REPRESENTS A FLUORINE ATOM OR A TRIFLUOROMETHYL GROUP, R1 AND R2 MAY BE THE SAME OR DIFFERENT AND REPRESENT A HYDROGEN ATOM OR AN ACYL GROUP, R3 REPRESENTS A HYDROGEN ATOM A HYDROXYL GROUP, AND (ii) AT LEAST ONE 1- [ (2- HYDROXYETHOXY) METHYL ] URACIL DERIVATIVE HAVING THE GENERAL FORMULA (II);(FORMULA 2) WHEREIN Y REPRESENTS A HYDROGEN ATOM, A HALOGEN ATOM, A METHYL GROUP, A BENZYL GROUP, A BENZYLOXY- BENZYL GROUP, A VINYL GROUP, A NITRO GROUP, OR AN AMINO GROUP AND R4 REPRESENTS A HYDROGEN ATOM OR AN ACYL GROUP. |