abstract |
DISUBSTITUTED N,N-PIPERAZINYL DERIVATIVES ARE DISCLOSED WHEREIN ONE SUBSTITUTED IS A PYRIMIDIN-2-YL RING AND THE OTHER IS A 4 CARBON CHAIN ATTACHED TO A P-FLUOROPHENYL RING AT THE TERMINAL CARBON. THE TERMINAL CARBON OF THIS BUTYLENE CHAIN IS ALSO BONDED TO AN OXYGENT ATOM AS PART OF A CARBONYL, CARBINOL OR KETAL FUNCTIONALITY. THESE COMPOUNDS POSSESS PYSCHOTROPIC PROPERTIES, PARTICULARLY A TYPICAL ANTIPSYCHOTIC ACTIVITY OF GOOD DURATION. BY VIRTUE OF PRE-CLINICAL PHARMACOLOGICAL TESTING, THESE COMPOUNDS APPEAR USEFUL AS POTENTIAL ANTIPSYCHOTIC AGENTS WHICH LACK THE TYPICAL MOVEMENT DISODER SIDE-EFFECTS OF STANDARD ANTIPSYCHOTIC AGENTS. |