abstract |
(S)-ALPHA-ETHYL-2-OXO-1-PYRROLIDINEACETAMIDE, ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. IT CAN BE PREPARED EITHER BY REACTING (S)-ALPHA-ETHYL-2-OXO-1-PYRROLIDINEACETIC ACID SUCCESSIVELY WITH AN ALKYL HALOFORMATE AND WITH AMMONIA, OR, BY CYCLIZING AN (S)-2-AMONI-BUTANAMIDE OF THE FORMULA X-CH2CH2-Y-NHCH(C2H5)CONH2 WHEREIN Y IS A -CH2- RADICAL WHEN X REPRESENTS A ZOOC- RADICAL AND Y IS A -CO- RADICAL WHEN X REPRESENTS HALCH2- RADICAL, Z BEING A C1-C4 ALKYL RADICAL AND HAL A HALOGEN ATOM. THIS LAEVOROTARY ENANTIOMER HAS BEEN FOUND TO HAVE SIGNIFICANTLY HIGHER PROTECTIVE ACTIVITY AGAINST HYPOXIA AND ISCHEMIA THAN THE CORRESPONDING RACEMATE. |