| abstract |
A PHARMACEUTICAL COMPOSITION FOR EXTERNAL USE WITH THE ENHANCED PENETRATION OF A PHARMACOLOGICALLY ACTIVE AGENT THROUGH THE SKIN OR MUCOSA OF A WARM-BLOODED ANIMAL, SAID COMPOSITION COMPRISING (A) A PHARMACEUTICALLY EFFECTIVE AMOUNT OF THE PHARMACOLOGICALLY ACTIVE AGENT SUCH AS ANTIINFLAMMATORY AGENT, ETC., AND (B) A PENETRATION ENHANCER OF THE FOLLOWING FORMULA (1) (FORMULA 1)WHEREIN R1 AND R2 ARE IDENTICAL OR DIFFERENT AND EACH REPRESENTS H, A C1-25 ALKYL, C2-25 ALKENYL, A (C1-24 ALKYL)CARBONYL OR A (C2-24 ANKENYL)CARBONYL, PROVIDED THAT R1 AND R2 ARE NOT H AT THE SAME TIME, OR R1 AND R2, TAKEN TOGETHER, MAY FORM A GROUP OF THE FOLLOWING FORMULA (A)(FORMULA ) IN WHICH R3 AND R4 ARE IDENTICAL OR DIFFERENT AND EACH REPRESENTS H, C1-24 ALKYL OR C1-24 ALKENYL. |