| abstract |
A process for the preparation of oxy-5 - ((R) -2-halo-1-hydroxy-ethyl) - (1H) -quinolin -2-one 8-substituted, or acceptable solvates thereof is described. The process involves reacting an oxy- (1 H) -quinolin-2-one 5- (a-haloacetyl) -8-substituted with a reducing agent in the presence of a chiral agent and a base, to form an 8- (oxy -substituted) -5 - ((R) -2-halo -1-hydroxy-ethyl) - (1H) -quinolin-2 -one, the chiral agent a Formula I or II (see Formula I or II): where M, L, X, R1, R2, and R3 have the meanings indicated in the specification. |