| abstract |
The compounds of structural formula I are androgen receptor (RA) modulators of a tissue selective mode; These compounds are useful in the improvement of weakened muscle tone and in the treatment of conditions caused by androgen deficiency or that can be alleviated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following reconstructive bone surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplasic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV consuncion, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancerous cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian insufficiency and autoimmune disease just oj along with other active agents. |