| abstract |
Dibenzofuran-4,6-dicarboxylic acid core structures are disclosed herein having an aromatic substituent attached at the C1 position, using three different types of bonds, and it is shown that they provide exceptional amyloidogenesis inhibitors that exhibit a higher affinity and a very increased binding selectivity with TTR over all other plasma proteins, in relation to the main compound 1. In addition, it is hereby disclosed that these compounds work by imposing a kinetic stabilization on the TTR tetramer. |