| abstract |
The present invention relates to Neisserial Lip-Oligo-Saccharides (LOS), comprising a tri-saccharide external nucleus that shows increased binding to the DC-SIGN receptor in dendritic cells, as a result of which, the Neiserial LOSs of the invention, they have increased immunostimulatory activity. The tri-sacral outer nucleus of the Neiserial LOSs, combined with a portion of Lipid A with reduced toxicity, is employed as an adjuvant in vaccine preparations. |