| abstract |
A novel pyrrolidine derivative represented by formula (I) or a salt thereof is provided, which has excellent DPP-IV inhibitory activity and excellent pharmacokinetics. Based on this action as such, the compound of the present invention is useful for the treatment and / or prevention of insulin-dependent diabetes mellitus (type 1 diabetes mellitus), and particularly non-insulin dependent diabetes mellitus (diabetes mellitus). type 2), insulin resistant diseases, obesity, etc. (see formula (I)) (In the formula, -A- represents a single bond, -O-, -S-, -NH- or -N (lower alkyl) -; and -B represents lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, or a non-aromatic heterocycle or an aromatic heterocycle, and each of these groups may be substituted). |