| abstract |
The present invention relates to 1,1,3-trisubstituted ureas having the formula: (I) wherein R, R1 and R2 are as defined in the claims, which inhibit the extracellular release of inflammatory cytokines; These cytokines are the cause of one or more disorders in humans or higher mammals. The present invention also relates to compositions comprising said 1,1,3-trisubstituted ureas which inhibit the release of extracellular inflammatory cytokines, and methods to prevent, decrease, or otherwise control the enzymes that are understood to be the components. assets responsible for the disorders described herein. |